Question: How high can alkaline phosphatase go?

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What is a high level of alkaline phosphatase?

High ALP usually means that either the liver has been damaged or a condition causing increased bone cell activity is present. If other liver tests such as bilirubin, aspartate aminotransferase (AST), or alanine aminotransferase (ALT) are also high, usually the increased ALP is caused by liver damage or disease.

Is 129 high for alkaline phosphatase?

Alkaline phosphatase is high if the blood levels surpass 130 U/L. High alkaline phosphatase doesn’t cause any symptoms directly. The symptoms will depend on your underlying health issue–such as liver or bone disorders.

What are the symptoms of high alkaline phosphatase?

Why do I need an alkaline phosphatase test?

  • Nausea and vomiting.
  • Weight loss.
  • Tiredness.
  • Weakness.
  • Jaundice, a condition that causes your skin and eyes to turn yellow.
  • Swelling and/or pain in your abdomen.
  • Dark-colored urine and/or light-colored stool.
  • Frequent Itching.

What is the treatment for high alkaline phosphatase?

A reduction in serum ALP was also seen in the euparathyroid subjects (2.4 +/- 0.77 to 2.2 +/- 0.64 mu kat/l, p = 0.03). This study indicates that treatment with active vitamin D is effective in reducing the increased bone turnover seen in subjects with both primary and secondary HPT.

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What is a normal alkaline phosphatase range?

The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (µkat/L). Normal values may vary slightly from laboratory to laboratory. They also can vary with age and sex. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women.

Can low vitamin D cause high alkaline phosphatase?

Thus, vitamin D deficiency is usually accompanied by normal blood levels for calcium and phosphorus, high-normal or elevated levels of PTH, normal to elevated levels of total alkaline phosphatase, a low 24-hour urine calcium excretion rate, and low levels of total 25(OH)D.

What foods increase alkaline phosphatase?

The diet containing phosphorus, healthy fats, Zn, vitamin B12 and vitamin A can be started to increase alkaline phosphatase level.

What medications cause high levels of alkaline phosphatase?

The following drugs may affect the level of alkaline phosphatase in the blood:

  • Allopurinol.
  • Antibiotics.
  • Anti-inflammatory medicines.
  • Birth control pills.
  • Certain diabetes medicines.
  • Chlorpromazine.
  • Cortisone.
  • Male hormones.

What bone disorders cause elevated alkaline phosphatase?

Bone pathology causes of elevated alkaline phosphatase include Paget’s disease, hyperparathyroidism, osteomalacia, metastatic bone disease and a recent fracture.

Is 70 a high ALT level?

Normal levels of AST and ALT may slightly vary depending on the individual laboratory’s reference values. Typically the range for normal AST is reported between 10 to 40 units per liter and ALT between 7 to 56 units per liter. Mild elevations are generally considered to be 2-3 times higher than the normal range.

Can high alkaline phosphatase cause itching?

Itching sometimes gets worse during pregnancy or if you’re undergoing hormone replacement therapy. Serum alkaline phosphatase (ALP). People with itch related to liver disease may have elevated ALP.

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What is a high ALT level?

Elevations in ALT generally are more specific for liver injury, whereas elevations in AST can also be caused by extrahepatic disorders, such as thyroid disorders, celiac sprue, hemolysis, and muscle disorders.7 Normal ALT levels are defined as 29 to 33 IU per L (0.48 to 0.55 μkat per L) for males and 19 to 25 IU per L

Can arthritis cause high alkaline phosphatase?

Increased concentration of serum alkaline phosphatase (ALP) is a common feature in rheumatoid arthritis (RA), although its origin remains unclear. The aim of this study is to analyze the origin and clinical significance of the elevated ALP value in RA.

When should I worry about Alt?

Very high levels may indicate liver problems, such as hepatitis. Very low levels of ALT may also pose health risks and increase frailty. One study found that low ALT levels in people with coronary heart disease increased the risk of long term mortality.

How do you evaluate high alkaline phosphatase?

To determine if elevated ALP is of liver origin, the authors recommended obtaining a GGT. A normal GGT indicates a nonhepatic origin of the ALP elevation. In these cases, the authors called for an assessment for vitamin D deficiency, primary hyperparathyroidism, and Paget’s disease.

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